Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection

• Main Authors: Luis Fernando Delgadillo-Silva (Author), Anastasia Tsakmaki (Author), Nadeem Akhtar (Author), Zara J. Franklin (Author), Judith Konantz (Author), Gavin A. Bewick (Author), Nikolay Ninov (Author)
• Format: Book
• Published: The Company of Biologists, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Islet inflammation and cytokine production are implicated in pancreatic β-cell dysfunction and diabetes pathogenesis. However, we lack therapeutics to protect the insulin-producing β-cells from inflammatory damage. Closing this clinical gap requires the establishment of new disease models of islet i...