Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection

• Glavni autori: Luis Fernando Delgadillo-Silva (Autor), Anastasia Tsakmaki (Autor), Nadeem Akhtar (Autor), Zara J. Franklin (Autor), Judith Konantz (Autor), Gavin A. Bewick (Autor), Nikolay Ninov (Autor)
• Format: Knjiga
• Izdano: The Company of Biologists, 2019-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Islet inflammation and cytokine production are implicated in pancreatic β-cell dysfunction and diabetes pathogenesis. However, we lack therapeutics to protect the insulin-producing β-cells from inflammatory damage. Closing this clinical gap requires the establishment of new disease models of islet i...