Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection

• Auteurs principaux: Luis Fernando Delgadillo-Silva (Auteur), Anastasia Tsakmaki (Auteur), Nadeem Akhtar (Auteur), Zara J. Franklin (Auteur), Judith Konantz (Auteur), Gavin A. Bewick (Auteur), Nikolay Ninov (Auteur)
• Format: Livre
• Publié: The Company of Biologists, 2019-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Islet inflammation and cytokine production are implicated in pancreatic β-cell dysfunction and diabetes pathogenesis. However, we lack therapeutics to protect the insulin-producing β-cells from inflammatory damage. Closing this clinical gap requires the establishment of new disease models of islet i...