Development of composite PLGA microspheres containing exenatide-encapsulated lecithin nanoparticles for sustained drug release

• Main Authors: Ni Dong (Author), Chune Zhu (Author), Junhuang Jiang (Author), Di Huang (Author), Xing Li (Author), Guilan Quan (Author), Yang Liu (Author), Wen Tan (Author), Xin Pan (Author), Chuanbin Wu (Author)
• Format: Book
• Published: Elsevier, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to prepare poly (D, L-lactic-co-glycolic acid) microspheres (PLGA-Ms) by a modified solid-in-oil-in-water (S/O/W) multi-emulsion technique in order to achieve sustained release with reduced initial burst and maintain efficient drug concentration for a prolonged period of time. Compo...