The Role of the Thioredoxin System in Brain Diseases

• Main Authors: Geir Bjørklund (Author), Lili Zou (Author), Massimiliano Peana (Author), Christos T. Chasapis (Author), Tony Hangan (Author), Jun Lu (Author), Michael Maes (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The thioredoxin system, consisting of thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH, plays a fundamental role in the control of antioxidant defenses, cell proliferation, redox states, and apoptosis. Aberrations in the Trx system may lead to increased oxidative stress toxicity and neurod...