Distinct antibody responses of patients with mild and severe leptospirosis determined by whole proteome microarray analysis.

• Main Authors: Carolina Lessa-Aquino (Author), Janet C Lindow (Author), Arlo Randall (Author), Elsio Wunder (Author), Jozelyn Pablo (Author), Rie Nakajima (Author), Algis Jasinskas (Author), Jaqueline S Cruz (Author), Alcineia O Damião (Author), Nívison Nery (Author), Guilherme S Ribeiro (Author), Federico Costa (Author), José E Hagan (Author), Mitermayer Galvão Reis (Author), Albert I Ko (Author), Marco Alberto Medeiros (Author), Philip L Felgner (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Leptospirosis is an important zoonotic disease worldwide. Humans usually present a mild non-specific febrile illness, but a proportion of them develop more severe outcomes, such as multi-organ failure, lung hemorrhage and death. Such complications are thought to depend on several factors,...