An overview of CDK3 in cancer: clinical significance and pharmacological implications

• Main Authors: Theodosia Teo (Author), Sara Kasirzadeh (Author), Hugo Albrecht (Author), Matthew J. Sykes (Author), Yuchao Yang (Author), Shudong Wang (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclin-dependent kinase 3 (CDK3) is a major player driving retinoblastoma (Rb) phosphorylation during the G0/G1 transition and in the early G1 phase of the cell cycle, preceding the effects of CDK4/cyclin D, CDK6/cyclin D, and CDK2/cyclin E. CDK3 can also directly regulate the activity of E2 factor...