NRF2/Itaconate Axis Regulates Metabolism and Inflammatory Properties of T Cells in Children with JIA

• Main Authors: Anandhi Rajendiran (Author), Sudheendra Hebbar Subramanyam (Author), Patricia Klemm (Author), Vera Jankowski (Author), Jorg van Loosdregt (Author), Bas Vastert (Author), Kristina Vollbach (Author), Norbert Wagner (Author), Klaus Tenbrock (Author), Kim Ohl (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: CD4+ T cells critically contribute to the initiation and perturbation of inflammation. When CD4+ T cells enter inflamed tissues, they adapt to hypoxia and oxidative stress conditions, and to a reduction in nutrients. We aimed to investigate how this distinct environment regulates T cell...