The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy

• Main Authors: Felice Gragnano (Author), Simona Sperlongano (Author), Enrica Golia (Author), Francesco Natale (Author), Renatomaria Bianchi (Author), Mario Crisci (Author), Fabio Fimiani (Author), Ivana Pariggiano (Author), Vincenzo Diana (Author), Andreina Carbone (Author), Arturo Cesaro (Author), Claudia Concilio (Author), Giuseppe Limongelli (Author), Mariagiovanna Russo (Author), Paolo Calabrò (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Beyond its role in hemostasis, von Willebrand factor (VWF) is an emerging mediator of vascular inflammation. Recent studies highlight the involvement of VWF and its regulator, ADAMTS13, in mechanisms that underlie vascular inflammation and immunothrombosis, like leukocyte rolling, adhesion, and extr...