Synthesis of [11C]carbonyl-labeled cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate ([11C-carbonyl]PK68) as a potential PET tracer for receptor-interacting protein 1 kinase

• Main Authors: Tomoteru Yamasaki (Author), Katsushi Kumata (Author), Atsuto Hiraishi (Author), Yiding Zhang (Author), Hidekatsu Wakizaka (Author), Yusuke Kurihara (Author), Nobuki Nengaki (Author), Ming-Rong Zhang (Author)
• Format: Book
• Published: SpringerOpen, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Receptor-interacting protein 1 kinase (RIPK1) is a key enzyme in the regulation of cellular necroptosis. Recently, cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate (PK68, 5) has been developed as a potent inhibitor of RIPK1. Herein, we synthesized [1...