Synthesis of [11C]carbonyl-labeled cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate ([11C-carbonyl]PK68) as a potential PET tracer for receptor-interacting protein 1 kinase

Abstract Background Receptor-interacting protein 1 kinase (RIPK1) is a key enzyme in the regulation of cellular necroptosis. Recently, cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate (PK68, 5) has been developed as a potent inhibitor of RIPK1. Herein, we synthesized [1...

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Hoofdauteurs: Tomoteru Yamasaki (Auteur), Katsushi Kumata (Auteur), Atsuto Hiraishi (Auteur), Yiding Zhang (Auteur), Hidekatsu Wakizaka (Auteur), Yusuke Kurihara (Auteur), Nobuki Nengaki (Auteur), Ming-Rong Zhang (Auteur)
Formaat: Boek
Gepubliceerd in: SpringerOpen, 2022-03-01T00:00:00Z.
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