Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice

• Main Authors: Ryan Brown (Author), Donna M. Small (Author), Declan F. Doherty (Author), Leslie Holsinger (Author), Robert Booth (Author), Richard Williams (Author), Rebecca J. Ingram (Author), J. Stuart Elborn (Author), Marcus A. Mall (Author), Clifford C. Taggart (Author), Sinéad Weldon (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Elevated levels of the cysteine protease cathepsin S (CatS) are associated with chronic mucoobstructive lung diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). We have previously demonstrated that prophylactic treatment with a CatS inhibitor from birt...