Bivalirudin Attenuates Thrombin-Induced Endothelial Hyperpermeability via S1P/S1PR2 Category: Original Articles

• Main Authors: Haowen Ye (Author), Yizhi Zhang (Author), Yihui Huang (Author), Biao Li (Author), Ruhao Cao (Author), Libing Dai (Author), Bin Huang (Author), Pingge Tian (Author), Li Li (Author), Yaling Han (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: To explore the role of the Sphingosine 1-Phosphate (S1P)/Receptor2 (S1PR2) pathway in thrombin-induced hyperpermeability (TIP) and to test whether bivalirudin can reverse TIP via the S1P-S1PRs pathway.Methods and Results: Using western blot, we demonstrated that Human umbilical vein endothelia...