Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains

• Main Authors: Taiki Shimizu (Author), Kenta Kanai (Author), Yui Sugawara (Author), Chiyoko Uchida (Author), Takafumi Uchida (Author)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain and functions as a mediator of calcium signaling. We found that the relative activity of CaMKII was significantly lower in the WT mouse brains than in the Pin1-/- mouse brains. Pin1 binds to phosphorylated CaMKII and we...