Effects of Pyruvate Kinase M2 (PKM2) Gene Deletion on Astrocyte-Specific Glycolysis and Global Cerebral Ischemia-Induced Neuronal Death

• Main Authors: Beom-Seok Kang (Author), Bo-Young Choi (Author), A-Ra Kho (Author), Song-Hee Lee (Author), Dae-Ki Hong (Author), Min-Kyu Park (Author), Si-Hyun Lee (Author), Chang-Juhn Lee (Author), Hyeun-Wook Yang (Author), Seo-Young Woo (Author), Se-Wan Park (Author), Dong-Yeon Kim (Author), Jae-Bong Park (Author), Won-Suk Chung (Author), Sang-Won Suh (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ischemic stroke is caused by insufficient blood flow to the brain. Astrocytes have a role in bidirectionally converting pyruvate, generated via glycolysis, into lactate and then supplying it to neurons through astrocyte-neuron lactate shuttle (ANLS). Pyruvate kinase M2 (PKM2) is an enzyme that depho...