RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland

• Main Authors: Laura McDonald (Author), Nicola Ferrari (Author), Anne Terry (Author), Margaret Bell (Author), Zahra M. Mohammed (Author), Clare Orange (Author), Alma Jenkins (Author), William J. Muller (Author), Barry A. Gusterson (Author), James C. Neil (Author), Joanne Edwards (Author), Joanna S. Morris (Author), Ewan R. Cameron (Author), Karen Blyth (Author)
• Format: Book
• Published: The Company of Biologists, 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RUNX2, a master regulator of osteogenesis, is oncogenic in the lymphoid lineage; however, little is known about its role in epithelial cancers. Upregulation of RUNX2 in cell lines correlates with increased invasiveness and the capacity to form osteolytic disease in models of breast and prostate canc...