RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland

• Автори: Laura McDonald (Автор), Nicola Ferrari (Автор), Anne Terry (Автор), Margaret Bell (Автор), Zahra M. Mohammed (Автор), Clare Orange (Автор), Alma Jenkins (Автор), William J. Muller (Автор), Barry A. Gusterson (Автор), James C. Neil (Автор), Joanne Edwards (Автор), Joanna S. Morris (Автор), Ewan R. Cameron (Автор), Karen Blyth (Автор)
• Формат: Книга
• Опубліковано: The Company of Biologists, 2014-05-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

RUNX2, a master regulator of osteogenesis, is oncogenic in the lymphoid lineage; however, little is known about its role in epithelial cancers. Upregulation of RUNX2 in cell lines correlates with increased invasiveness and the capacity to form osteolytic disease in models of breast and prostate canc...