Diversity of Solid Forms Promoted by Ball Milling: Characterization and Intrinsic Dissolution Studies of Pioglitazone Hydrochloride and Fluvastatin Sodium Drug-Drug Systems

• Main Authors: Marco Villeda-Villegas (Author), José C. Páez-Franco (Author), Guadalupe Coyote-Dotor (Author), Alejandra Núñez-Pineda (Author), Alejandro Dorazco-González (Author), Inés Fuentes-Noriega (Author), Kenneth Rubio-Carrasco (Author), Helen P. Toledo Jaldín (Author), David Morales-Morales (Author), Juan Manuel Germán-Acacio (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Coamorphous salt in a 1:1 ratio prepared by ball milling from Fluvastatin sodium (FLV) and Pioglitazone hydrochloride (PGZ·HCl) can be selectively formed by neat grinding (NG). Furthermore, the salt-cocrystal continuum was preferably formed by employing liquid-assisted grinding (LAG) using ethanol (...