Novel disease syndromes unveiled by integrative multiscale network analysis of diseases sharing molecular effectors and comorbidities

• Main Authors: Haiquan Li (Author), Jungwei Fan (Author), Francesca Vitali (Author), Joanne Berghout (Author), Dillon Aberasturi (Author), Jianrong Li (Author), Liam Wilson (Author), Wesley Chiu (Author), Minsu Pumarejo (Author), Jiali Han (Author), Colleen Kenost (Author), Pradeep C. Koripella (Author), Nima Pouladi (Author), Dean Billheimer (Author), Edward J. Bedrick (Author), Yves A. Lussier (Author)
• Format: Book
• Published: BMC, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Forty-two percent of patients experience disease comorbidity, contributing substantially to mortality rates and increased healthcare costs. Yet, the possibility of underlying shared mechanisms for diseases remains not well established, and few studies have confirmed their molecul...