In vitro and in vivo Human Metabolism of (S)-[18F]Fluspidine - A Radioligand for Imaging σ1 Receptors With Positron Emission Tomography (PET)

• Egile Nagusiak: Friedrich-Alexander Ludwig (Egilea), Steffen Fischer (Egilea), Richard Houska (Egilea), Alexander Hoepping (Egilea), Winnie Deuther-Conrad (Egilea), Dirk Schepmann (Egilea), Marianne Patt (Egilea), Philipp M. Meyer (Egilea), Swen Hesse (Egilea), Georg-Alexander Becker (Egilea), Franziska Ruth Zientek (Egilea), Jörg Steinbach (Egilea), Bernhard Wünsch (Egilea), Osama Sabri (Egilea), Peter Brust (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

(S)-[18F]fluspidine ((S)-[18F]1) has recently been explored for positron emission tomography (PET) imaging of sigma-1 receptors in humans. In the current report, we have used plasma samples of healthy volunteers to investigate the radiometabolites of (S)-[18F]1 and elucidate their structures with LC...