In vitro and in vivo Human Metabolism of (S)-[18F]Fluspidine - A Radioligand for Imaging σ1 Receptors With Positron Emission Tomography (PET)

• Main Authors: Friedrich-Alexander Ludwig (Author), Steffen Fischer (Author), Richard Houska (Author), Alexander Hoepping (Author), Winnie Deuther-Conrad (Author), Dirk Schepmann (Author), Marianne Patt (Author), Philipp M. Meyer (Author), Swen Hesse (Author), Georg-Alexander Becker (Author), Franziska Ruth Zientek (Author), Jörg Steinbach (Author), Bernhard Wünsch (Author), Osama Sabri (Author), Peter Brust (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

(S)-[18F]fluspidine ((S)-[18F]1) has recently been explored for positron emission tomography (PET) imaging of sigma-1 receptors in humans. In the current report, we have used plasma samples of healthy volunteers to investigate the radiometabolites of (S)-[18F]1 and elucidate their structures with LC...