Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration

• Main Authors: Yuki Inoue (Author), Masamitsu Shimazawa (Author), Ryota Nagano (Author), Yoshiki Kuse (Author), Kei Takahashi (Author), Kazuhiro Tsuruma (Author), Masahiro Hayashi (Author), Takashi Ishibashi (Author), Takashi Maoka (Author), Hideaki Hara (Author)
• Format: Book
• Published: Elsevier, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Carotenoids, in particular astaxanthin, possess potent antioxidant capabilities. Astaxanthin also induces NF-E2-related factor 2 (Nrf2), which plays a major regulatory role in the antioxidative response. However, little is known whether the carotenoid, by-products of astaxanthin, activate Nrf2. Towa...