Enhanced delivery efficiency and sustained release of biopharmaceuticals by complexation-based gel encapsulated coated microneedles: rhIFNα-1b example

Coated microneedles (MNs) are widely used for delivering biopharmaceuticals. In this study, a novel gel encapsulated coated MNs (GEC-MNs) was developed. The water-soluble drug coating was encapsulated with sodium alginate (SA) in situ complexation gel. The manufacturing process of GEC-MNs was optimi...

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Main Authors: Zequan Zhou (Author), Suohui Zhang (Author), Guozhong Yang (Author), Yunhua Gao (Author)
Format: Book
Published: Elsevier, 2021-09-01T00:00:00Z.
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