Antigen Protease Activity on Intact or Tape-Stripped Skin Induces Acute Itch and T Helper Sensitization Leading to Airway Eosinophilia in Mice

• Main Authors: Toru Kimitsu (Author), Seiji Kamijo (Author), Tomoko Yoshimura (Author), Yurie Masutani (Author), Saya Shimizu (Author), Keiko Takada (Author), Punyada Suchiva (Author), Hideoki Ogawa (Author), Ko Okumura (Author), Shigaku Ikeda (Author), Toshiro Takai (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Respiratory allergen sources such as house dust mites frequently contain proteases. In this study, we demonstrated that the epicutaneous application of a model protease antigen, papain, onto intact or tape-stripped ear skin of mice induced acute scratching behaviors and T helper (Th)2, Th9, Th17/Th2...