Towards a Quantitative Mechanistic Understanding of Localized Pulmonary Tissue Retention-A Combined In Vivo/In Silico Approach Based on Four Model Drugs

• Hoofdauteurs: Anneke Himstedt (Auteur), Clemens Braun (Auteur), Sebastian Georg Wicha (Auteur), Jens Markus Borghardt (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2020-04-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Increasing affinity to lung tissue is an important strategy to achieve pulmonary retention and to prolong the duration of effect in the lung. As the lung is a very heterogeneous organ, differences in structure and blood flow may influence local pulmonary disposition. Here, a novel lung preparation t...