Effects of the Novel IDO Inhibitor DWG-1036 on the Behavior of Male and Female 3xTg-AD Mice

• Main Authors: Emre Fertan (Author), Kurt R.J. Stover (Author), Michael G. Brant (Author), Paul M. Stafford (Author), Brendan Kelly (Author), Elena Diez-Cecilia (Author), Aimée A. Wong (Author), Donald F. Weaver (Author), Richard E. Brown (Author)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

The kynurenine pathway metabolizes tryptophan into nicotinamide adenine dinucleotide, producing a number of intermediary metabolites, including 3-hydroxy kynurenine and quinolinic acid, which are involved in the neurodegenerative mechanisms that underlie Alzheimer's disease (AD). Indolamine 2,3...