Sphingomyelinase activity promotes atrophy and attenuates force in human muscle fibres and is elevated in heart failure patients

• Main Authors: Karl Olsson (Author), Arthur J. Cheng (Author), Mamdoh Al‐Ameri (Author), Nicolas Tardif (Author), Michael Melin (Author), Olav Rooyackers (Author), Johanna T. Lanner (Author), Håkan Westerblad (Author), Thomas Gustafsson (Author), Joseph D. Bruton (Author), Eric Rullman (Author)
• Format: Book
• Published: Wiley, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Activation of sphingomyelinase (SMase) as a result of a general inflammatory response has been implicated as a mechanism underlying disease‐related loss of skeletal muscle mass and function in several clinical conditions including heart failure. Here, for the first time, we chara...