Enhanced drug classification using machine learning with multiplexed cardiac contractility assays

• Main Authors: Reza Aghavali (Author), Erin G. Roberts (Author), Yosuke K. Kurokawa (Author), Erica Mak (Author), Martin Y.C. Chan (Author), Andy O.T. Wong (Author), Ronald A. Li (Author), Kevin D. Costa (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cardiac screening of newly discovered drugs remains a longstanding challenge for the pharmaceutical industry. While therapeutic efficacy and cardiotoxicity are evaluated through preclinical biochemical and animal testing, 90 % of lead compounds fail to meet safety and efficacy benchmarks during huma...