Enhanced drug classification using machine learning with multiplexed cardiac contractility assays
Cardiac screening of newly discovered drugs remains a longstanding challenge for the pharmaceutical industry. While therapeutic efficacy and cardiotoxicity are evaluated through preclinical biochemical and animal testing, 90 % of lead compounds fail to meet safety and efficacy benchmarks during huma...
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Main Authors: | Reza Aghavali (Author), Erin G. Roberts (Author), Yosuke K. Kurokawa (Author), Erica Mak (Author), Martin Y.C. Chan (Author), Andy O.T. Wong (Author), Ronald A. Li (Author), Kevin D. Costa (Author) |
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Format: | Book |
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Elsevier,
2024-11-01T00:00:00Z.
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Online Access: | Connect to this object online. |
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