Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect

• Main Authors: Stefania Petrosino (Author), Marika Cordaro (Author), Roberta Verde (Author), Aniello Schiano Moriello (Author), Gabriele Marcolongo (Author), Carlo Schievano (Author), Rosalba Siracusa (Author), Fabiana Piscitelli (Author), Alessio F. Peritore (Author), Rosalia Crupi (Author), Daniela Impellizzeri (Author), Emanuela Esposito (Author), Salvatore Cuzzocrea (Author), Vincenzo Di Marzo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Palmitoylethanolamide (PEA) is a pleiotropic lipid mediator with established anti-inflammatory and anti-hyperalgesic activity. Ultramicronized PEA (PEA-um) has superior oral efficacy compared to naïve (non-micronized) PEA. The aim of the present study was two-fold: (1) to evaluate whether oral PEA-u...