Doxycycline reduces MMP-2 activity and inhibits invasion of 12Z epithelial endometriotic cells as well as MMP-2 and -9 activity in primary endometriotic stromal cells in vitro

Abstract Background Matrix metalloproteinases (MMPs), especially the gelatinases MMP-2 and MMP-9, play a crucial role in the pathogenesis of endometriosis by enabling invasion. Doxycycline is a well-tolerated antibiotic and a potent MMP-inhibitor in subantimicrobial doses. Methods Gelatin zymography...

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主要な著者: Eleftherios P. Samartzis (著者), Daniel Fink (著者), Manuel Stucki (著者), Patrick Imesch (著者)
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出版事項: BMC, 2019-04-01T00:00:00Z.
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3rd Floor Main Library

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