Doxycycline reduces MMP-2 activity and inhibits invasion of 12Z epithelial endometriotic cells as well as MMP-2 and -9 activity in primary endometriotic stromal cells in vitro
Abstract Background Matrix metalloproteinases (MMPs), especially the gelatinases MMP-2 and MMP-9, play a crucial role in the pathogenesis of endometriosis by enabling invasion. Doxycycline is a well-tolerated antibiotic and a potent MMP-inhibitor in subantimicrobial doses. Methods Gelatin zymography...
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| Main Authors: | , , , |
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| Format: | Book |
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BMC,
2019-04-01T00:00:00Z.
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |