Profile of Antiemetic Activity of Netupitant Alone or in Combination with Palonosetron and Dexamethasone in Ferrets and Suncus murinus (house musk shrew)

• Autores principales: John A Rudd (Autor), Man P. Ngan (Autor), Zengbing Lu (Autor), Guy A. Higgins (Autor), Claudio Giuliano (Autor), Emanuela Lovati (Autor), Claudio Pietra (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2016-08-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Background and Aims: Chemotherapy-induced acute and delayed emesis involves the activation of multiple pathways, with 5-hydroxytryptamine (5-HT; serotonin) playing a major role in the initial response. Substance P tachykinin NK1 receptor antagonists can reduce emesis induced by disparate emetic chal...