Carnosic Acid Alleviates BDL-Induced Liver Fibrosis through miR-29b-3p-Mediated Inhibition of the High-Mobility Group Box 1/Toll-Like Receptor 4 Signaling Pathway in Rats

• Main Authors: Shuai Zhang (Author), Zhecheng Wang (Author), Jie Zhu (Author), Ting Xu (Author), Yan Zhao (Author), Huanyu Zhao (Author), Fan Tang (Author), Zhenlu Li (Author), Junjun Zhou (Author), Dongyan Gao (Author), Xiaofeng Tian (Author), Jihong Yao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fibrosis reflects a progression to liver cancer or cirrhosis of the liver. Recent studies have shown that high-mobility group box-1 (HMGB1) plays a major role in hepatic injury and fibrosis. Carnosic acid (CA), a compound extracted from rosemary, has been reported to alleviate alcoholic and non-alco...