Cardiovascular and Respiratory Toxicity of Protamine Sulfate in Zebrafish and Rodent Models

• Main Authors: Joanna Miklosz (Author), Bartlomiej Kalaska (Author), Piotr Podlasz (Author), Małgorzata Chmielewska-Krzesińska (Author), Miłosz Zajączkowski (Author), Adam Kosiński (Author), Dariusz Pawlak (Author), Andrzej Mogielnicki (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Protamine sulfate (PS) is the only available option to reverse the anticoagulant activity of unfractionated heparin (UFH), however it can cause cardiovascular and respiratory complications. We explored the toxicity of PS and its complexes with UFH in zebrafish, rats, and mice. The involvement of nit...