A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy

• Main Authors: Gerhard Frey (Author), Ana Paula G. Cugnetti (Author), Haizhen Liu (Author), Charles Xing (Author), Christina Wheeler (Author), Hwai Wen Chang (Author), William J. Boyle (Author), Jay M. Short (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTEpithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein that plays several roles in cancer biology. EpCAM is an attractive therapeutic target because of its expression in most solid tumors. However, targeting EpCAM has been challenging because it is also highly expressed in...