New benzothieno[2,3-c]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and in silico ADME profile studies

New benzothieno[2,3-c]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and in silico ADME profile studies

A series of [1]benzothieno[2,3-c]pyridines was synthesised. Most compounds were chosen by NCI-USA to evaluate their anticancer activity. Compounds 5a-c showed prominent growth inhibition against most cell lines. 5c was selected at five dose concentration levels. It exhibited potent broad-spectrum an...

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Main Authors: Nadia A. Khalil (Author), Eman M. Ahmed (Author), Ashraf F. Zaher (Author), Eman A. Sobh (Author), Samiha A. El-Sebaey (Author), Mona S. El-Zoghbi (Author)
Format: Book
Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
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