cAMP Signaling Enhances HIV-1 Long Terminal Repeat (LTR)-directed Transcription and Viral Replication in Bone Marrow Progenitor Cells

• Hauptverfasser: Anupam Banerjee (Verfasst von), Luna Li (Verfasst von), Vanessa Pirrone (Verfasst von), Fred C Krebs (Verfasst von), Brian Wigdahl (Verfasst von), Michael R Nonnemacher (Verfasst von)
• Format: Buch
• Veröffentlicht: SAGE Publishing, 2017-03-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

CD34 + hematopoietic progenitor cells have been shown to be susceptible to HIV-1 infection, possibly due to a low-level expression of CXCR4, a coreceptor for HIV-1 entry. Given these observations, we have explored the impact of forskolin on cell surface expression of CXCR4 in a cell line model (TF-1...