cAMP Signaling Enhances HIV-1 Long Terminal Repeat (LTR)-directed Transcription and Viral Replication in Bone Marrow Progenitor Cells

• Main Authors: Anupam Banerjee (Author), Luna Li (Author), Vanessa Pirrone (Author), Fred C Krebs (Author), Brian Wigdahl (Author), Michael R Nonnemacher (Author)
• Format: Book
• Published: SAGE Publishing, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CD34 + hematopoietic progenitor cells have been shown to be susceptible to HIV-1 infection, possibly due to a low-level expression of CXCR4, a coreceptor for HIV-1 entry. Given these observations, we have explored the impact of forskolin on cell surface expression of CXCR4 in a cell line model (TF-1...