A Wnt10a-Notch signaling axis controls Hertwig's epithelial root sheath cell behaviors during root furcation patterning

• Main Authors: Kai Sun (Author), Miao Yu (Author), Jiayu Wang (Author), Hu Zhao (Author), Haochen Liu (Author), Hailan Feng (Author), Yang Liu (Author), Dong Han (Author)
• Format: Book
• Published: Nature Publishing Group, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Human with bi-allelic WNT10A mutations and epithelial Wnt10a knockout mice present enlarged pulp chamber and apical displacement of the root furcation of multi-rooted teeth, known as taurodontism; thus, indicating the critical role of Wnt10a in tooth root morphogenesis. However, the endogen...