Biphasic Production of Anti-ApoB100 Autoantibodies in Obese Humans and Mice

• Prif Awduron: Moon Kyung Choe (Awdur), Hyung-Ji Kim (Awdur), Nan Hee Kim (Awdur), Bert Binas (Awdur), Hyo Joon Kim (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2021-04-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Obesity is associated with autoimmunity, a phenomenon considered as harmful. Here we show that obese mice and humans produce IgG-type autoantibodies that specifically recognize apolipoprotein B-100 (ApoB100), its native epitope p210, and the synthetic p210 mimotope pB1. By contrast, antibodies again...