Design and synthesis of novel oridonin analogues as potent anticancer agents

• Main Authors: Qing-Kun Shen (Author), Zheng-Ai Chen (Author), Hong-Jian Zhang (Author), Jia-Li Li (Author), Chuan-Feng Liu (Author), Guo-Hua Gong (Author), Zhe-Shan Quan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To identify anticancer agents with higher potency and lower toxicity, a series of oridonin derivatives with substituted benzene moieties at the C17 position were designed, synthesised, and evaluated for their antiproliferative properties. Most of the derivatives exhibited antiproliferative effects a...