Differences in tissue distribution ability of evodiamine and dehydroevodiamine are due to the dihedral angle of the molecule stereo-structure

Introduction: This researcher focused at the evodiamine and dehydroevodiamine tissue distribution and structure-pharmacokinetics (PK) relationship after intravenous injection in mice.Methods: Using a transmembrane transport experiment, the permeability of evodiamine and dehydroevodiamine on Caco-2 c...

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Main Authors: Jie Luo (Author), Wen Wen (Author), Jie Chen (Author), Xiaobo Zeng (Author), Ping Wang (Author), Shijun Xu (Author)
Format: Book
Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
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