Improved Therapeutic Delivery Targeting Clinically Relevant Orthotopic Human Pancreatic Tumors Engrafted in Immunocompromised Pigs Using Ultrasound-Induced Cavitation: A Pilot Study

• Main Authors: Khan Mohammad Imran (Author), Benjamin Tintera (Author), Holly A. Morrison (Author), Juselyn D. Tupik (Author), Margaret A. Nagai-Singer (Author), Hannah Ivester (Author), McAlister Council-Troche (Author), Michael Edwards (Author), Sheryl Coutermarsh-Ott (Author), Christopher Byron (Author), Sherrie Clark-Deener (Author), Kyungjun Uh (Author), Kiho Lee (Author), Paul Boulos (Author), Cliff Rowe (Author), Christian Coviello (Author), Irving C. Allen (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic tumors can be resistant to drug penetration due to high interstitial fluid pressure, dense stroma, and disarrayed vasculature. Ultrasound-induced cavitation is an emerging technology that may overcome many of these limitations. Low-intensity ultrasound, coupled with co-administered cavita...