Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling

• Main Authors: J. Porter Hunt (Author), Samuel Dubinsky (Author), Autumn M. McKnite (Author), Kit Wun Kathy Cheung (Author), Bianca D. vanGroen (Author), Kathleen M. Giacomini (Author), Saskia N. deWildt (Author), Andrea N. Edginton (Author), Kevin M. Watt (Author)
• Format: Book
• Published: Wiley, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Optimal treatment of infants with many renally cleared drugs must account for maturational differences in renal transporter (RT) activity. Pediatric physiologically‐based pharmacokinetic (PBPK) models may incorporate RT activity, but this requires ontogeny profiles for RT activity in childr...