Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas' disease.

• Main Authors: Paulo Marcos Matta Guedes (Author), Fredy Roberto Salazar Gutierrez (Author), Grace Kelly Silva (Author), Renata Dellalibera-Joviliano (Author), Gerson Jhonatan Rodrigues (Author), Lusiane Maria Bendhack (Author), Anis Rassi (Author), André Schmidt (Author), Benedito Carlos Maciel (Author), José Antonio Marin Neto (Author), João Santana Silva (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Myocardium damage during Chagas' disease results from the immunological imbalance between pro- and production of anti-inflammatory cytokines and has been explained based on the Th1-Th2 dichotomy and regulatory T cell activity. Recently, we demonstrated that IL-17 produced during exp...