Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas' disease.

• Hoofdauteurs: Paulo Marcos Matta Guedes (Auteur), Fredy Roberto Salazar Gutierrez (Auteur), Grace Kelly Silva (Auteur), Renata Dellalibera-Joviliano (Auteur), Gerson Jhonatan Rodrigues (Auteur), Lusiane Maria Bendhack (Auteur), Anis Rassi (Auteur), André Schmidt (Auteur), Benedito Carlos Maciel (Auteur), José Antonio Marin Neto (Auteur), João Santana Silva (Auteur)
• Formaat: Boek
• Gepubliceerd in: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

BACKGROUND: Myocardium damage during Chagas' disease results from the immunological imbalance between pro- and production of anti-inflammatory cytokines and has been explained based on the Th1-Th2 dichotomy and regulatory T cell activity. Recently, we demonstrated that IL-17 produced during exp...