Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function

• Main Authors: Gretchen Wolff (Author), Minako Sakurai (Author), Amit Mhamane (Author), Maria Troullinaki (Author), Adriano Maida (Author), Ioannis K. Deligiannis (Author), Kelvin Yin (Author), Peter Weber (Author), Jakob Morgenstern (Author), Annika Wieder (Author), Yun Kwon (Author), Revathi Sekar (Author), Anja Zeigerer (Author), Michael Roden (Author), Matthias Blüher (Author), Nadine Volk (Author), Tanja Poth (Author), Thilo Hackert (Author), Lena Wiedmann (Author), Francesca De Angelis Rigotti (Author), Juan Rodriguez-Vita (Author), Andreas Fischer (Author), Rajesh Mukthavaram (Author), Pattraranee Limphong (Author), Kiyoshi Tachikawa (Author), Priya Karmali (Author), Joseph Payne (Author), Padmanabh Chivukula (Author), Bilgen Ekim-Üstünel (Author), Celia P. Martinez-Jimenez (Author), Julia Szendrödi (Author), Peter Nawroth (Author), Stephan Herzig (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Fibrotic organ responses have recently been identified as long-term complications in diabetes. Indeed, insulin resistance and aberrant hepatic lipid accumulation represent driving features of progressive non-alcoholic fatty liver disease (NAFLD), ranging from simple steatosis and non-alco...