Late-stage modification of bioactive compounds: Improving druggability through efficient molecular editing

• Main Authors: Tongyu Huo (Author), Xinyi Zhao (Author), Zengrui Cheng (Author), Jialiang Wei (Author), Minghui Zhu (Author), Xiaodong Dou (Author), Ning Jiao (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Synthetic chemistry plays an indispensable role in drug discovery, contributing to hit compounds identification, lead compounds optimization, candidate drugs preparation, and so on. As Nobel Prize laureate James Black emphasized, "the most fruitful basis for the discovery of a new drug is to st...