High drug loading hydrophobic cross-linked dextran microspheres as novel drug delivery systems for the treatment of osteoarthritis

• Main Authors: Zhimin Li (Author), Xianjing Feng (Author), Shixing Luo (Author), Yanfeng Ding (Author), Zhi Zhang (Author), Yifeng Shang (Author), Doudou Lei (Author), Jinhong Cai (Author), Jinmin Zhao (Author), Li Zheng (Author), Ming Gao (Author)
• Format: Book
• Published: Elsevier, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug delivery via intra-articular (IA) injection has proved to be effective in osteoarthritis (OA) therapy, limited by the drug efficiency and short retention time of the drug delivery systems (DDSs). Herein, a series of modified cross-linked dextran (Sephadex, S0) was fabricated by respectively gra...