Inactivation of TFEB and NF-κB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion

• Main Authors: Huanmin Niu (Author), Lilin Qian (Author), Bin Sun (Author), Wenjian Liu (Author), Fang Wang (Author), Qian Wang (Author), Xiaotian Ji (Author), Yanhai Luo (Author), Effat Un Nesa (Author), Hongxiang Lou (Author), Huiqing Yuan (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It is critical to regulate the senescence-associated secretory phenotype (SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that marchantin M (Mar-M, a naturally occurring bisbibenzyl) suppressed pro-inflammatory S...