Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells

• Main Authors: Eva M García-Recio (Author), Celia Pinto-Díez (Author), M Isabel Pérez-Morgado (Author), Marta García-Hernández (Author), Gerónimo Fernández (Author), M Elena Martín (Author), Víctor M González (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Elevated expression levels of eukaryotic initiation factor 4E (eIF4E) promote cancer development and progression. MAP kinase interacting kinases (MNKs) modulate the function of eIF4E through the phosphorylation that is necessary for oncogenic transformation. Therefore, pharmacologic MNK inhibitors m...