Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells

• Главные авторы: Eva M García-Recio (Автор), Celia Pinto-Díez (Автор), M Isabel Pérez-Morgado (Автор), Marta García-Hernández (Автор), Gerónimo Fernández (Автор), M Elena Martín (Автор), Víctor M González (Автор)
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• Опубликовано: Elsevier, 2016-01-01T00:00:00Z.
• Предметы: article
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Elevated expression levels of eukaryotic initiation factor 4E (eIF4E) promote cancer development and progression. MAP kinase interacting kinases (MNKs) modulate the function of eIF4E through the phosphorylation that is necessary for oncogenic transformation. Therefore, pharmacologic MNK inhibitors m...