Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells

• 主要な著者: Eva M García-Recio (著者), Celia Pinto-Díez (著者), M Isabel Pérez-Morgado (著者), Marta García-Hernández (著者), Gerónimo Fernández (著者), M Elena Martín (著者), Víctor M González (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2016-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Elevated expression levels of eukaryotic initiation factor 4E (eIF4E) promote cancer development and progression. MAP kinase interacting kinases (MNKs) modulate the function of eIF4E through the phosphorylation that is necessary for oncogenic transformation. Therefore, pharmacologic MNK inhibitors m...