Versatile Solid Modifications of Multicomponent Pharmaceutical Salts: Novel Metformin-Rhein Salts Based on Advantage Complementary Strategy Design

• Main Authors: Mingchao Yu (Author), Meidai Liang (Author), Qi An (Author), Wenwen Wang (Author), Baoxi Zhang (Author), Shiying Yang (Author), Jian Zhou (Author), Xiuying Yang (Author), Dezhi Yang (Author), Li Zhang (Author), Guanhua Du (Author), Yang Lu (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to develop an effective treatment for diabetes and diabetic complications, based on the advantage complementary strategy of drug-drug salt, by designing and synthesizing the multicomponent molecular salts containing metformin (MET) and rhein (RHE). Finally, the salts of MET-RHE (1:1...