Gut dysbiosis aggravates cognitive deficits, amyloid pathology and lipid metabolism dysregulation in a transgenic mouse model of Alzheimer's disease

Gut dysbiosis, a well-known risk factor to triggers the progression of Alzheimer's disease (AD), is strongly associated with metabolic disturbance. Trimethylamine N-oxide (TMAO), produced in the dietary choline metabolism, has been found to accelerate neurodegeneration in AD pathology. In this...

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Main Authors: Chang Qu (Author), Qing-Qing Xu (Author), Wen Yang (Author), Mei Zhong (Author), Qiuju Yuan (Author), Yan-Fang Xian (Author), Zhi-Xiu Lin (Author)
Format: Book
Published: Elsevier, 2023-12-01T00:00:00Z.
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