Continuous Inhibition of Sonic Hedgehog Signaling Leads to Differentiation of Human-Induced Pluripotent Stem Cells into Functional Insulin-Producing β Cells

• Main Authors: Song Lee (Author), Jae Hyun Joo (Author), Ju Yun Oh (Author), Eun Ha Seo (Author), Yang Hee Kim (Author), Eunsung Jun (Author), In Kyong Shim (Author), Song Cheol Kim (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human-induced pluripotent stem cell- (iPSC-) derived insulin-producing cells (IPCs) can be used for islet cell transplantation into type 1 diabetic patients and as patient-specific cells for the development of novel antidiabetic drugs. However, a method is needed to generate functional IPCs from iPS...