Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions

• Главные авторы: Guiomar Rodríguez-Periñán (Автор), Ana de la Encarnación (Автор), Fermín Moreno (Автор), Adolfo López de Munain (Автор), Ana Martínez (Автор), Ángeles Martín-Requero (Автор), Carolina Alquézar (Автор), Fernando Bartolomé (Автор)
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• Опубликовано: MDPI AG, 2023-02-01T00:00:00Z.
• Предметы: article
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Loss-of-function (LOF) mutations in <i>GRN</i> gene, which encodes progranulin (PGRN), cause frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). FTLD-TDP is one of the most common forms of early onset dementia, but its pathogenesis is not fully understood. Mitochondrial...