Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions

• Asıl Yazarlar: Guiomar Rodríguez-Periñán (Yazar), Ana de la Encarnación (Yazar), Fermín Moreno (Yazar), Adolfo López de Munain (Yazar), Ana Martínez (Yazar), Ángeles Martín-Requero (Yazar), Carolina Alquézar (Yazar), Fernando Bartolomé (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2023-02-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Loss-of-function (LOF) mutations in <i>GRN</i> gene, which encodes progranulin (PGRN), cause frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). FTLD-TDP is one of the most common forms of early onset dementia, but its pathogenesis is not fully understood. Mitochondrial...