Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions
Loss-of-function (LOF) mutations in <i>GRN</i> gene, which encodes progranulin (PGRN), cause frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). FTLD-TDP is one of the most common forms of early onset dementia, but its pathogenesis is not fully understood. Mitochondrial...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
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MDPI AG,
2023-02-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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